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Immunologic Defects in Laboratory Animals 1 pp Cite as. The virtual absence of any cell-mediated immune response in these animals has proved to be of great value both in the study of the immune system itself and as a tool in many areas of applied research, particularly in the study of cancer and infectious disease. Similar mutations in the rat and guinea pig should also be of value as tools in studying the immunobiology of these two species, and for research in which the mouse may not be entirely suitable e. At the same time, study of these additional species should throw light on the generality of the observed biological effects of thymic aplasia in the mouse. Unable to display preview.